Testosterone Propionate Solubility

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Background: Various studies have reported the effects of testosterone on different cell types, yet bone marrow-derived mesenchymal stem cells' cellular responses to testosterone remain unknown. Aims: To investigate the effects of testosterone propionate, an oil-soluble short-acting form of testosterone, on human bone marrow-derived mesenchymal stem cells' proliferation and viability after . Identification Summary. Testosterone propionate is a slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles. . Generic Name Testosterone propionate DrugBank Accession Number DB01420 Background. Testosterone propionate is a slower-releasing anabolic steroid with a short half-life. Testosterone propionate 5 Day(s) Mouse Oral 1000 mg/kg/day NOAEL None identified IARC: Group 2A Revision date: 10-Feb-2010 OSHA: Present Testosterone propionate 28 Day(s) Monkey Subcutaneous 2. 7 mg/kg/day LOAEL Endocrine system Not specified Rat Subcutaneous 80-100 mg LOEL Tumors, Male reproductive systemTestosterone propionate (4-Androsten-17β-ol-3-one 17-propionate ); solid; Testosterone propionate has been used for studying its effects on pregnant ewes ; Androgen; Androgens direct the development of the male phenotype during embryogenesis and at puberty; . soluble 1 in 6 of ethanol, 1 in 4 of acetone, 1 in 20 of ethyl oleate, and 1 in 30 . It is practically insoluble in water, soluble 1 in 6 of ethanol, 1 in 4 of acetone, 1 in 20 of ethyl oleate, and 1 in 30 of propylene glycol. The product is incompatible with alkalis and oxidizing agents; it should be protected from light. References The Merck Index, 10th ed. , Entry# 9006. J. AOAC 45, 797 (1962). Mainwaring, W. I. ,The aqueous solubility and rat skin permeation rate of each drug, saturated in various compositions of an ethanol/water system, was determined at 37 degrees C. . Testosterone propionate was found to be stable in the isotonic buffer solution and in the epidermis-side extract for 10h at 37 degrees C. However, in the skin homogenate and the . Pharmacology Pharmacodynamics Testosterone propionate is a prodrug of testosterone and is an androgen and anabolic-androgenic steroid (AAS). That is, it is an agonist of the androgen receptor (AR). Pharmacokinetics Testosterone propionate is administered in oil via intramuscular injection. Testosterone Propionate Solubility. Testosterone propionate is a common anabolic steroid used in bodybuilding and sports. It is an ester of testosterone and has a short half-life. One of the crucial factors to consider while using testosterone propionate is its solubility. Solubility is the measure of how much of the steroid can dissolve in a . Due to its lipophilic character, TU is soluble in non-polar solvents but shows a satisfactory solubility in absolute ethanol. Based on the molecular structure, a moderate absorption in the. Testosterone propionate | C22H32O3 | CID 5995 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. JavaScript is required. Please enable Javascript in order to use PubChem website. 288. 4 g/mol Computed by PubChem 2. 1 (PubChem release 2021. 05. 07) Dates Create: 2004-09-16 Modify: 2023-09-23 Description Testosterone is an androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5. . It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. Abstract The solubility parameters of a range of saturated hydrocarbons were calculated from vapor pressures and heats of vaporization. Solubilities of testosterone propionate were determined in these solvents at 25 degrees and yielded solute solubility parameters which varied from solvent to solvent. Testosterone and derivatives. Widely used in the past for a variety of conditions, testosterone is of no clinical use in small animal reproduction. The 19-nor-steroid mibolerone is the only related drug of use. EXAMPLES. Testosterone cypionate, testosterone propionate and testosterone ethanate are synthetic esters of testosterone. The recommended dose is 25 to 50 mg of testosterone propionate (2 mg/kg) intramuscularly given at 3-week intervals for up to three preoperative doses. 14, 155 In Europe dihydrotestosterone transdermal gel has also proven to be effective. 156 I have not found the routine use of testosterone stimulation to be beneficial. In severe cases when the . Testosterone fatty acid esters at the 17 position prolongs IM retention and duration of activity of testosterone commensurate with fatty acid length (Figure 1). 49 When administered IM, 3 the androgen ester is slowly absorbed into the circulation where it is then rapidly metabolized to active unesterified testosterone. Testosterone propionate, a short fatty acid, releases testosterone for only . Testosterone Propionate (T-PRO) for intramuscular injection, contains Testosterone Propionate which is the oil-soluble 4-androstene-3-one,17beta-ol of the androgenic hormone testosterone. Testosterone propionate is attached to a short ester and so 100mg of Testosterone Propionate contains 83. 72mg of testosterone which is more testosterone than . 1 of 4 Description Application Testosterone propionate has been used for studying its effects on pregnant ewes [1], [2]. Biochem/physiol Actions Androgens direct the development of the male phenotype during embryogenesis and at puberty. The solubility parameter of testosterone propionate was determined by several other methods, and support was found for the previously published figure of 9. 5 cal 1/2 cm −3/2. The geometric mean coefficient ( l12) in saturated hydrocarbons was found to be a rectilinear function of the branching ratio ( r ). solid Synonym (s): 17β-Hydroxy-4-androsten-3-one 17-propionate, 17β-Propionyloxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one 17-propionate Empirical Formula (Hill Notation): C22H32O3 CAS Number: 57-85-2 Molecular Weight: 344. 49 Beilstein: 3221760 EC Number: 200-351-1 MDL number: MFCD00003653 PubChem Substance ID: 24899994 NACRES: NA. 77To investigate the effects of testosterone propionate, an oil-soluble short-acting form of testosterone, on human bone marrow-derived mesenchymal stem cells' proliferation and viability after 24 hours of incubation. Testosterone phenylpropionate is a steroid indicated for testosterone . Comp 250 (Testosterone Decanoate, Testosterone Isocaproate, Testosterone Phenylpropionate, Testosterone Propionate) Injection ; External Links KEGG Compound C14667 ChemSpider 14062 RxNav . Water Solubility: 0. 000283 mg/mL: ALOGPS: logP: 4. 61: ALOGPS: logP: 6. 09 . Testosterone, solubility Oil-soluble derivatives of testosterone itself predate those of its 19-nor congener these agents too are used to administer depot injections so as to provide in effect long-term blood levels of drug. Thus, acylation of testosterone with propionyl chloride in the presence of pyridine yields testosterone propionate (76a)acylation by means of decanoic anhydride yields . The level of solubilization of the drug testosterone propionate into 2% w/w oil-in-water (o/w) microemulsions, stabilized by the nonionic surfactant polyoxyethylene 10-oleyl ether (Brij 96) and containing a range of oils, has been determined.

Testosterone propionate | C22H32O3 | CID 5995 - PubChem Spectrophotometric and chromatographic strategies for exploring of the . Testosterone phenylpropionate - DrugBank Online TPRO 100 - Testosterone Propionate | IA Superpharma USA-Lite Skin permeation of testosterone and its ester derivatives in rats Testosterone propionate - Wikipedia Solubilities of testosterone propionate and related esters in organic . Testosterone Propionate - an overview | ScienceDirect Topics Testosterone propionate solubility | The Role of pH in the Solubility . Testosterone Propionate Promotes Proliferation and Viability of Bone . Effect of oil on the level of solubilization of testosterone propionate . Testosterone propionate solid 57-85-2 - MilliporeSigma PDF Testosterone propionate (T1875) - Product Information Sheet Testosterone | C19H28O2 | CID 6013 - PubChem PDF MATERIAL SAFETY DATA SHEET - Pfizer Testosterone, solubility - Big Chemical Encyclopedia Testosterone Propionate - an overview | ScienceDirect Topics Testosterone propionate solid 57-85-2 - MilliporeSigma Testosterone propionate - DrugBank Online Testosterone Propionate - an overview | ScienceDirect Topics Solubilities of testosterone propionate and related esters in organic . Testosterone propionate solid 57-85-2 - MilliporeSigma Testosterone Propionate Promotes Proliferation and Viability . - PubMed